Carbamazepine erythromycin drug interaction
Drug Interaction Categories Contraindicated Never use this combination of drugs because of high risk for dangerous interaction. In the pig the sensitivity of carbamazepine metabolism to erythromycin was much greater than in the rat, indicating the existence of a large species difference in this particular drug interaction.
Drug interactions with carbamazepine oral and erythromycin oral
In rats erythromycin significantly depressed the elimination of carbamazepine in animals induced with carbamazepine for 4 days but had no effect on carbamazepine elimination in noninduced animals. J Clin Psychiatry Mar;47 3: Do not start, stop, or change the dosage of any medicine before checking with them first.
We report four cases of carbamazepine toxicity in children associated with the concurrent administration of erythromycin. Contraindicated unless benefits outweigh risks and no alternatives available.
When these two medicines are taken together, your body may not process your carbamazepine properly. Use the arrow keys to navigate suggestions. Available for Android and iOS devices. Women's Health Find out what women really need.
Multiple case reports and pharmacokinetic studies in humans and animals have established that erythromycin causes carbamazepine toxicity when the two drugs are administered concurrently. Carbamazepine intoxication due to triacetyloleandomycin administration in epileptic patients. Check for more interactions with the Drug Interaction Checker.
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Serious - Use Alternative High likelihood serious or life-threatening interaction. Carbamazepine intoxication following the use of erythromycin in children. Purchase access Subscribe now. Information For Readers For Authors. How to cite this comment: Contact your healthcare professionals e.
Author Affiliations Durham, NC. Vyzulta Vyzulta latanoprostene bunod ophthalmic solution is a nitric oxide donating prostaglandin It is concluded that the interaction between erythromycin and carbamazepine is caused by a direct inhibition of carbamazepine oxidation by the antibiotic.
Br J Clin Pharmacol Dec; 24 6: Every effort has been made to ensure that the information provided by Multum is accurate, up-to-date and complete, but no guarantee is made to that effect.