Cotrimoxazole effect on warfarin
Clin Pharmacol Ther Jun;17 6: Westfall reported a woman who bled menorrhagia while taking warfarin and doxycycline mg daily for 8 days. Weser JK, Sellers E.
With localized medical news and in-language editions. Drugs Jun;25 6: Circulation Sep;52 3: Earn course certificates and optional CME. Clin Pharmacy ; 8: When these two medicines are taken together, your body may not process your blood-thinner properly. Am J Hosp Pharm ; Vancomycin possibly causes a small increase in the effects of warfarin. Spec Care Dentist ; The risk of an interaction appears to exist when given therapeutically as an extended course, as opposed to when given as a single dose.
Preregistration trainees Pharmaceutical jobs. What you should do about this interaction: Trimethoprim can cause a depression of haematopoiesis by interfering with the metabolism of folic acid, particularly if it is given in high doses or for long periods. These factors are synthesised in the liver in precursor form and are activated by carboxylation of specific glutamic acid residues which require vitamin K in its reduced form as a cofactor.
It is apparent that conflict often exists between scientific studies and case reports which illustrates the fact that the response to warfarin therapy can be unpredictable and guidelines on management should take into account the rare and sometimes serious sequelae. Drug Intell Clin Pharm ; Warfarin potentiated by proguanil. For more information please take a look at our terms and conditions.
Danos reported a marked increase in INR 2 to 7. There is, currently, only one case report of clindamycin interacting with warfarin and, in that instance, in addition to the prophylactic dose, it had been used as a 7-day therapeutic dose for local infection. Among the most well-known interactions thought to occur by this mechanism are those with phenytoin and warfarin.
A reduction in the activity and concentration of all four factors is embraced by the portmanteau term 'hypoprothrombinaemia'.
Interaction of sulfisoxazole and warfarin. It has been shown that low dose 1 mg oral vitamin K can effectively reduce INR within 24 hours in warfarinised patients who develop asymptomatic increases in INR.