Does imuran cause birth defects

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Patients on Imuran should have complete blood counts, including platelet counts, weekly during the first month, twice monthly for the second and third months of treatment, then monthly or more frequently if dosage alterations or other therapy changes are necessary. The reaction can recur within hours after re-challenge with a single dose of Imuran. The mechanisms whereby azathioprine affects autoimmune diseases are not known. I'm considering going off Aza to see how my body reacts without it before TTCing.

Hi there, I have been taking 50mg of Imuran since It is recommended that a further dose reduction or alternative therapies be considered for patients with low or absent TPMT activity receiving Imuran and allopurinol because both TPMT and XO inactivation pathways are affected.

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I've been on mg Aza Imuran for about 13 years. I welcome any opinions you may want to send my way and thank you for giving me the oportunity to unburden Azathioprine is metabolized to 6-mercaptopurine 6-MP.

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Use in Renal Dysfunction: Will have to see my consultant again as this changes things- don't want to start on Azathioprine now Abnormalities included skeletal malformations and visceral anomalies. The structural formula of azathioprine is:. While the drug should be avoided for the treatment of rheumatoid arthritis during pregnancy whenever possible; there are situations when it is the best drug to help ensure the woman's health, such as when Imuran is used to stop kidney transplant rejection.

Well as it happens she was big!


The optimum duration of maintenance Imuran has not been determined. So far, everything is normal and we've had no issues. I didn't have an amnio, I wasn't aware that we were at increased risk for anything other than low birth weight. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skillknowledge, and judgement of healthcare practitioners in patient care.

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Multum Information Services, Inc. Azathioprine is well absorbed following oral administration.

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Overview Side Effects Dosage More. Imuran is usually given on a daily basis. A few days later after 16 hours of pretty sore labour Jack was born weighing 6lbs 14 oz and was just perfect.

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I've got a prescription to start Azathioprine It is an imidazolyl derivative of 6-mercaptopurine and many of its biological effects are similar to those of the parent compound. To view content sources and attributions, please refer to our editorial policy. If you have taken any medicines it is always a good idea to let your doctor know that you are pregnant so that you can decide together whether you still need the medicines that you are on and to make sure that you are taking the lowest dose that works.

Azathioprine is immunosuppressive, delayed hypersensitivity and cellular cytotoxicity tests being suppressed to a greater degree than are antibody responses. Hi All, I have just found this forum and it is exactly what I need right now.