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Careful consideration should be given if diazepam is to be combined with other psychotropic agents phenothiazines, barbiturates, MAO inhibitors and other antidepressants because the pharmacological action of these agents might potentiate the action of diazepam.
The metabolism of phenytoin may be increased or decreased or remain unaltered by diazepam in an unpredictable way. These reactions are more likely in children and the elderly, and extreme caution should be used in prescribing benzodiazepines to patients with personality disorders. Enhanced sedation or respiratory and cardiovascular depression with sedative antihistamines.
Decreased elimination may also occur in some elderly patients due to a decline in renal function and can either intensify or prolong the adverse reactions of the drug. Although the combination has been used safely, adverse reactions such as confusion, ataxia, somnolence, delirium, collapse, cardiac arrest, respiratory arrest, and death have occurred rarely in patients receiving clozapine concurrently or following benzodiazepine therapy.
Diazepam is a useful adjunct for the relief of skeletal muscle spasm due to reflex spasm to local pathology such as inflammation of the muscles or joints, or secondary to trauma ; spasticity caused by upper motor neuron disorders such as cerebral palsy and paraplegia ; athetosis; stiff-man syndrome; and tetanus.
In some cases the use of a narcotic may not be necessary. Benzodiazepines may also have other actions. Several benzodiazepines, including clonazepam, oxazepam, flurazepam, diazepam, clobazam, flunitrazepam, and lorazepam have been implicated in these reactions.
In addition, children born to mothers receiving benzodiazepines on a regular basis late in pregnancy may be at some risk of experiencing withdrawal symptoms during the postnatal period.
Controlled studies in pregnant women show no evidence of fetal risk. Patients should be warned of the possibility of drowsiness that may impair performance of potentially hazardous tasks such as driving an automobile or operating machinery.
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The safety and efficacy in obstetrics have not yet been established. While diazepam clearance may be inhibited, diazepam pharmacodynamics are not always affected. Moderate Coadministration of diazepam and digoxin has been reported to increase the half-life of digoxin due to reduced urinary excretion of digoxin. The side effects of diazepam are usually mild and infrequent. Due to long-acting metabolite, not considered a drug of choice in the elderly; associated with falls.
IV 6 months-5 years: Find medicines from the same company. Moderate Concomitant administration of benzodiazepines with CNS-depressant drugs, including opiate agonists, can potentiate the CNS effects of either agent.
Itraconazole Increased plasma concentration of diazepam due to inhibition of the CYP3A4 metabolic pathway. The solution should be injected slowly, taking at least one minute for each 5 mg 1 mL given. Neurelis Pharmaceuticals, Inc; B N. Due to the myorelaxant effect there is a risk of falls and consequently hip fractures in the elderly.
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