Cetirizine hplc analysis

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Method development and validation for the simulthaneous determination of cetirizine dihydrocholride, paracetamol, and phenylpropanolamine hydrochloride in tablets by capillary zone electrophoresis J. The drug concentration was determined in comparison with the same concentration of a standard solution of cetirizine dihydrochloride.

The mobile phase was prepared daily and degassed by filtration through a 0. The aim of this study was to validate an HPLC method according to the ICH guidelines to be performed for kinetic study of the degradation of cetirizine dihydrochloride under acidic, basic and oxidative degradation processes. The limit of quantification was nano grams, while the limit of detection was 0.

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Cetirizine dihydrochloride is a potent and non-sedating antihistamine belongs to the piperazine class of second generation of antihistamines.

There are some reports in the literature about the stability of cetirizine dihydrochloride in different conditions. Int J Pharm Sci Res ; 6 9: Deshmukh gratefully acknowledges the funding supports rendered by the R.

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How to cite this comment: Cetirizine dihydrochloride is used for symptomatic treatment of allergic conditions including seasonal rhinitis and chronic urticaria 1. An accurately weighed portion of powder equivalent to 10 mg cetirizine was transferred to a mL volumetric flask and 50 mL of mobile phase was added.

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Mumbai for providing gift sample of Phenylepherine Hydrochloride and Cetirizine Hydrochloride and thankful to Qualichem Lab. The wavelength for UV-detection was nm and all determinations were performed at ambient temperature. The intermediate precision was also studied by comparison of the assay results for cetirizine tablets by two analysts using two different HPLC systems. Twenty cetirizine dihydrochloride tablets were weighed and ground into fine powder using a glass mortar and pestle.

The results are given in Table 6. Pseudo-first-order plots for the degradation of cetirizine dihydrochloride in 0.


Abstract A simple, sensitive, reliable and rapid HPLC method for the determination of cetirizine hydrochloride using hyoscine butyl bromide as an internal standard has been developed. Stability indicating HPTLC method for the simultaneous determination of pseudoephendrine and cetirizine in pharmaceutical formulations. The same method was performed during three separate days to find out the between-day precision and accuracy. The degradation of cetirizine dihydrochloride was investigated in acidic condition using 2M hydrochloric acid.

A linear relationship was observed by plotting the 1og of residual percent cetirizine dihydrochloride versus time Figure 3 which indicates a pseudo-first-order kinetics according to the following equation:. Please review our privacy policy. Article Information Sr No: The drug was found to degrade in this condition at different temperatures with a same pattern Figure 2b.