Co-diovan 80/12.5 precio
The following adverse reactions have been reported in patients treated with monotherapy of thiazide diuretics, including hydrochlorothiazide: Thiazide-induced hypokalaemia or hypomagnesaemia may occur as undesirable effects favouring the onset of digitalis-induced cardiac arrhythmias see section 4. Monitoring of potassium should be undertaken as appropriate. These doses in marmoset, respectively, represent 0.
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However, these tests were performed separately with valsartan and hydrochlorothiazide, and produced no evidence of mutagenicity, chromosomal breakage or carcinogenicity. Frequency of adverse reactions with hydrochorothiazide.
Each film-coated tablet contains mg valsartan and Hydrochlorothiazide is excreted in human milk. Concomitant treatment with ciclosporin may increase the risk of hyperuricaemia and gout-type complications.
Distribution The steady-state volume of distribution of valsartan after intravenous administration is about 17 litres, indicating that valsartan does not distribute into tissues extensively.
In drug interaction studies with valsartan, no interactions of clinical significance have been found with valsartan or any of the following substances: Patients with primary hyperaldosteronism should not be treated with Co-Diovan as their renin-angiotensin system is not activated. Find medicines with the same active ingredients. Co-Diovan should not be used in these patients.
Concomitant use not recommended. Conversely, it is anticipated that prokinetic drugs such as cisapride may decrease the bioavailability of thiazide-type diuretics. Serum electrolyte changes Valsartan Concomitant use with potassium supplements, potassium-sparing diuretics, salt substitutes containing potassium, or other agents that may increase potassium levels heparin, etc.
The use of Co-Diovan in patients with severe chronic heart failure has not been established. Co-administration of inhibitors of the uptake transporter eg. Blood and lymphatic system disorders. Photosensitivity Cases of photosensitivity reactions have been reported with thiazide diuretics see section 4.
The increase in mean AUC is linear and dose proportional in the therapeutic range.
Adverse drug reactions are ranked by frequency, the most frequent first, using the following convention: