Prednisolone sodium succinate
Prednisolone Sodium Succinate [usp: The larger doses may be required for short-term management of severe, acute conditions.
Corticosteroids should not be stopped and the dose may need to be increased. As with all drugs, corticosteroids should only be prescribed when the benefits to the mother and child outweigh the risks. Tell your doctor right away if you have any serious side effects, including: These effects are less likely to occur with the synthetic derivatives except when used in large doses.
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Dosage may be reduced for infants and children but should be governed more by the severity of the condition and response of the patient than by age or size.
Chickenpox is of serious concern since this normally minor illness may be fatal in the immunosuppressed patients. In the presence of a CYP3A4 inhibitor, the dose of methylprednisolone may need to be titrated to avoid steroid toxicity.
To prevent these withdrawal symptoms when stopping methylprednisoloneyour doctor may reduce your dose gradually. In some instances this alteration of the inflammatory reaction may be beneficial, however, it may also mask the signs of infection and tend to facilitate the spread of micro-organisms.
Injection site reaction; fatigue; malaise; withdrawal symptoms — too rapid a reduction of corticosteroid dosage following prolonged treatment can lead to acute adrenal insufficiency; hypotension and death. Before using this medicationtell your doctor or pharmacist your medical history, especially of: Although doses and protocols have varied in studies using methylprednisolone sodium succinate in the treatment of graft rejection reactions, the published literature supports the use of doses of this level, with mg to 1 g most commonly used for acute rejection.
Patients should carry 'Steroid Treatment' cards which can give clear guidance on the precautions to be taken to minimise risk and which provide details of prescriber, drug, dosage and duration of treatment. Doses up to mg should be given intravenously over a period of at least five minutes. Abrupt withdrawal of doses up to 32 mg daily of methylprednisolone for 3 weeks is unlikely to lead to clinically relevant HPA-axis suppression, in the majority of patients.
Medical advice should be sought immediately if exposure occurs. There was no evidence of a potential for genetic and chromosome mutations in limited studies performed in bacteria and mammalian cells. Frequent patient monitoring is necessary in patients with congestive heart failure or recent myocardial infarction myocardial rupture has been reported. Undesirable effects may be minimised by using the lowest effective dose for the minimum period see Other special warnings and precautions.
Growth may be suppressed in children receiving long- term, daily divided-dose glucocorticoid therapy and use of such regimen should be restricted to the most urgent indications.
Adverse effects of glucocorticoids on the cardiovascular system, such as dyslipidemia and hypertension, may predispose treated patients with existing cardiovascular risk factors to additional cardiovascular effects, if high doses and prolonged courses are used.
Frequent patient monitoring is necessary in patients with existing or previous history of severe affective disorders especially previous steroid psychosis. Sodium Prednisolone hemisuccinate The initial dose usually should be given intravenously over a period of several minutes. Persons who are on immunosuppressant doses of corticosteroids should be warned to avoid exposure to chicken pox or measles.