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Store in original container in order to protect from light. Following oral administration, plasma concentrations of losartan and its active metabolite decline polyexponentially, with a terminal half-life of about 2 hours and hours, respectively. Cozaar Rating 53 User Reviews 6. No overall differences in effectiveness or safety were observed between these patients and younger patients, but greater sensitivity of some older individuals cannot be ruled out.

Discuss treatment options with women planning to become pregnant. If you think you might have a medical emergency, call your doctor or immediately.

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Skip to side effects section. In repeated dose toxicity studies, the administration of losartan induced a decrease in the red blood cell parameters erythrocytes, haemoglobin, haematocrita rise in urea-N in the serum and occasional rises in serum creatinine, a decrease in heart weight without a histological correlate and gastrointestinal changes mucous membrane lesions, ulcers, erosions, haemorrhages. In controlled clinical studies, once - daily administration of losartan to patients with mild to moderate essential hypertension produced statistically significant reductions in systolic and diastolic blood pressure.

The dose should generally be titrated at weekly intervals i.

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Monitor serum potassium in such patients. Perform serial ultrasound examinations to assess the intra-amniotic environment. GoodRx is not sponsored by or affiliated with any of the pharmacies identified in its price comparisons.

Get our free fact sheet. The mean length of follow up was 4. No studies on the effects on the ability to drive and use machines have been performed.

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Harm to fetus Liver damage Heart problems due to high potassium. Cardiovascular death and stroke were both numerically more frequent in the aliskiren group than in the placebo group and adverse events and serious adverse events of interest hyperkalaemia, hypotension and renal dysfunction were more frequently reported in the aliskiren group than in the placebo group.

The use of losartan is contraindicated during the 2 nd and 3 rd trimester of pregnancy see section 4.

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The sitting diastolic blood pressure SiDBP on entry into the study was higher than the 95 th percentile level for the patient's age, gender, and height. Resulting oligohydramnios can be associated with fetal lung hypoplasia and skeletal deformations. After discontinuation of losartan, PRA and angiotensin II values fell within three days to the baseline values.

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Patients with proteinuria and a serum creatinine of 1. Conversion of losartan to its active metabolite after intravenous administration is not affected by ketoconazole, an inhibitor of P 3A4.

Patients whose renal function may depend in part on the activity of the renin-angiotensin system e.

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