Dose range of digoxin
Major Measure serum digoxin concentrations before initiating tetracyclines. Carefully monitor serum digoxin concentrations; observe patients carefully for signs of digoxin toxicity. Increased monitoring of digoxin concentrations is recommended during concurrent use.
However, toxicity may occur with lower digoxin serum concentrations. Isradipine causes no change in serum digoxin levels. Quantity Limits Drugs that have quantity limits associated with each prescription.
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LBW 70 to 79 kg: Major Because of the potential for additive or synergistic depressant effects on SA and AV nodes, regadenoson should be used with caution in the presence of agents that slow cardiac conduction, especially digoxin.
Multiple rhythm disturbances in the same patient are common. Other Restrictions Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription. Ventricular arrhythmias are less common.
Adding plans allows you to compare formulary status to other drugs in the same class. Flibanserin increased the digoxin AUC by 2. Hypocalcemia can nullify the effects of digoxin in humans; thus, digoxin may be ineffective until serum calcium is restored to normal.
Monitor for signs and symptoms of digoxin toxicity and clinical response. In the majority of cases however, the major route of digoxin elimination is renal excretion of the unchanged drug. Free E-newsletter Subscribe to Housecall Our general interest e-newsletter keeps you up to date on a wide variety of health topics.
Arrhythmia, conduction disturbances, bigeminy, trigeminy, PR prolongation, sinus bradycardia Very rare: Peak cardiac effects generally occur 3 to 6 hours following overdosage and may persist for the ensuing 24 hours or longer. In addition, when calcium is administered via rapid intravenous injection, the risk of serious arrhythmias in digitalized patients is increased.
The use of therapeutic doses of digoxin may cause prolongation of the PR interval and depression of the ST segment on the electrocardiogram. Patients with moderate-severe renal insufficiency should receive smaller loading doses than patients with normal renal function due to a reduced volume of distribution.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
Most manifestations of toxicity in children occur during or shortly after the loading phase with digoxin. The dose of Lanoxin for each patient has to be tailored individually according to age, lean body weight and renal function.
Moderate Digoxin serum concentrations have been reported to increase when hydroxychloroquine was added.