Donepezil hydrochloride accord
There is also the potential for synergistic activity with concomitant treatment involving medications such as succinylcholine, other neuro-muscular blocking agents or cholinergic agonists or beta blocking agents which have effects on cardiac conduction.
Cholinomimetics are believed to have some potential to cause generalised convulsions. Treatment should be initiated and supervised by a physician experienced in the diagnosis and treatment of Alzheimer's dementia. Children and adolescents Donepezil Hydrochloride is not recommended for use in children and adolescents. Donepezil Hydrochloride should be taken orally, in the evening, just prior to retiring. We comply with the HONcode standard for trustworthy health information - verify here.
Upon discontinuation of treatment, a gradual abatement of the beneficial effects of Donepezil Hydrochloride is seen. Therefore, women on donepezil should not breast feed. Drug interaction studies performed in vitro show that ketoconazole and quinidine, inhibitors of CYP3A4 and 2D6 respectively, inhibit donepezil metabolism.
The mortality rate for the three VaD studies combined in the donepezil hydrochloride group 1. Lactose monohydrate Maize starch Cellulose microcrystalline Low-substituted hydroxypropyl cellulose Magnesium stearate Tablet Coating. Qualitative and quantitative composition Each film-coated tablet contains: The metabolism of donepezil hydrochloride is not affected by concurrent administration of digoxin or cimetidine.
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Over dosage with cholinesterase inhibitors can result in cholinergic crisis characterized by severe nausea, vomiting, salivation, sweating, bradycardia, hypotension, respiratory depression, collapse and convulsions. Reporting suspected adverse reactions after authorisation of the medicinal product is important.
Pharmaceutical form Film-coated tablet White to off-white, round, approximately 7. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Since the magnitude of an inhibiting or inducing effect is unknown, such drug combinations should be used with care.
Reporting of suspected adverse reactions. Furthermore, donepezil can induce fatigue, dizziness and muscle cramps, mainly when initiating or increasing the dose.
Musculoskeletal and connective tissue disorders. There have been reports of syncope and seizures. Because of their pharmacological action, cholinesterase inhibitors may have vagotonic effects on heart rate e.
Donepezil Hydrochloride, as a cholinesterase inhibitor, is likely to exaggerate succinylcholine-type muscle relaxation during anaesthesia. Donepezil hydrochloride a derivative of Donepezil is reported as an ingredient of Donepezil Hydrochloride Accord in the following countries:. An analysis of all serious non-fatal and fatal vascular events showed no difference in the rate of occurrence in the donepezil hydrochloride group relative to placebo.