Amiodarone infusion solution

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This products label may have been revised after this insert was used in production. Elderly patients should be closely monitored during treatment, particularly for thyroid function. There has been limited experience in patients receiving amiodarone injection for longer than 3 weeks.

Patients should be monitored for QTc prolongation during infusion with Cordarone I. Similar concentrations for similar duration. Intravenous amiodarone is a useful addition to the drugs available for the treatment of patients with very severe ventricular arrhythmia. The following table provides suggested doses of oral Cordarone to be initiated after varying durations of Cordarone I.

However, the possibility of cardiac defects should be kept in mind.

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The clinical and radiographic picture can arise after a variety of lung injuries, such as those resulting from traumashockprolonged cardiopulmonary resuscitationand aspiration pneumoniaconditions present in many of the patients enrolled in the clinical studies. Qualitative and quantitative composition 3. No fertility studies were conducted with intravenous amiodarone. It is well known that amiodarone adsorbs to polyvinyl chloride PVC tubing and the clinical trial dose administration schedule was designed to account for this adsorption.

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These differences between oral and intravenous administration suggest that the initial acute effects of amiodarone injection may be predominantly focused on the AV node, causing an intranodal conduction delay and increased nodal refractoriness due to slow channel blockade class IV activity and noncompetitive adrenergic antagonism class II activity.

Repeated or continuous infusion via peripheral veins may lead to injection site reactions see section 4. These antithyroid actions of amiodarone might contribute to its cardiac electrophysiological effects. IV Loading dose limited data: For both studies, the median rate was 0. Amiodarone hydrochloride has a long half-life which varies interindividually between 20 and days. Sign up to bookmark this SPC already have an account? Only 1 of more than patients treated with Cordarone I.

Thus, although a starting dose adequate to suppress life-threatening arrhythmias is needed, close monitoring with adjustment of dose as needed is essential.

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Quinidine and procainamide doses should be reduced by one-third when either is administered with amiodarone. Neither amiodarone nor DEA is dialyzable. The maintenance infusion was continued up to hour