Minocycline multiple sclerosis treatment
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Online travel sites get squeezed by Airbnb, hotel chains. Acne antibiotic delays development of multiple sclerosis in small trial. Global Resource for Healthcare Professionals. Intention to treat analysis included subjects, as one subject was randomized in error; 72 received minocycline. Supported by the Multiple Sclerosis Society of Canada.
The study team used minocycline because it has anti-inflammatory properties and, unlike most drugs, it crosses the blood-brain barrier. Earn course certificates and optional CME. How is minocycline taken?
Sign Up It's Free! During the period from January through Julywe randomly assigned participants who had had their first demyelinating symptoms within the previous days to receive either mg of minocycline, administered orally twice daily, or placebo. The proportion of active scans was lower during the first six months of treatment 5. The absolute risk reduction was All secondary MRI outcomes favored minocycline over placebo at 6 months but not at 24 months.
Disease and Condition Articles. Trial withdrawals and adverse events of rash, dizziness, and dental discoloration were more frequent among participants who received minocycline than among those who received placebo. Research Our research story Latest research Treatments in the pipeline How are treatments developed?
This article is available to subscribers. This trial is limited by small sample and no control group but suggests that minocycline is safe and potentially beneficial in RRMS. Current multiple sclerosis MS treatment is only partially effective and not all patients respond well.
Common side effects in people treated with minocycline include diarrhoea, dizziness or lightheadedness, dental discolouration, sun sensitivity and fungal infections.
Estimates of the cumulative percentage of participants with conversion to MS were calculated with the use of actuarial life-table analyses, stratified according to the number of lesions enhanced on magnetic resonance imaging at baseline. The curves show the cumulative percentage of participants who had a clinically isolated syndrome and subsequently underwent conversion to MS diagnosed according to the McDonald criteria over the course of 24 months.
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