Does nurofen plus contain ibuprofen
Nurofen Plus mg Tablets is developed with a combination of Ibuprofen and Codeine to help you double the efforts of relieving your pain than taking a single painkiller alone. Codeine phosphate is well absorbed after oral administration, producing peak plasma concentrations in about one hour.
However, if the patient is an ultra-rapid metaboliser of CYP2D6, higher levels of the active metabolite, morphine, may be present in breast milk and on very rare occasions may result in symptoms of opioid toxicity in the infant, which may be fatal. No more than the stated dose of this medicine should be taken. Do not use for more than 3 days, it can cause addiction.
Combination therapy with protective agents e. Codeine is metabolised by the liver enzyme CYP2D6 into morphine, its active metabolite.
However, if the patient is an ultra-rapid metaboliser of CYP2D6, higher levels of the active metabolite, morphine, may be present in breast milk and on very rare occasions may result in symptoms of opioid toxicity in the infant, which may be fatal.
If you take the medicine according to the instructions on the pack it is unlikely that you will become addicted to the medicine. Concurrent use of hydroxyzine anxiolytics with codeine may result in increased analgesia as well as increased CNS depressant, sedative and hypotensive effects.
Haemogloblin decreased, urea renal clearance decreased. The risk of GI bleeding, ulceration or perforation is higher with increasing NSAID doses, in patients with a history of ulcer, particularly if complicated with haemorrhage or perforation see section 4.
If you are elderly or particularly if you are receiving regular treatment from your doctor, consult your doctor before taking this medicine. Supply through pharmacy only. Although there are uncertainties regarding the extrapolation of these data to the clinical situation, the possibility that regular, long-term use of ibuprofen may reduce the cardioprotective effect of low-dose acetylsalicylic acid cannot be excluded.
Patients who have previously shown hypersensitivity reactions e. Within each frequency grouping, adverse events are presented in order of decreasing seriousness. This class of medicine is in the list of drugs included in regulations under 5a of the Road Traffic Act There is an increased risk of aseptic meningitis in patients with Systemic lupus erythematoses and mixed connective tissue disease using the active ingredients in this product see section 4.