Drug class trileptal
Phenytoin may decrease serum concentrations of oxcarbazepine. Patients receiving these drugs concurrently should be monitored for clinical effect. Share cases and questions with Physicians on Medscape consult. Seizures diazepamtopiramatelevetiracetamTopamaxValiumKeppraprimidoneDilantinoxcarbazepinephenobarbitalphenytoinpyridoxineMore Major Clozapine has an established risk of seizures, which may compromise the effectiveness of oxcarbazepine in the treatment of seizure disorders.
Oxcarbazepine mg-ROX, peach, oblong. Major A reduction in seizure threshold has been reported following concomitant administration of pemoline with anticonvulsant agents.
Brain and Nervous System Topics
According to the OBRA guidelines, some anticonvulsants may be used to treat disorders other than seizures e. Moderate The phenothiazines, when used concomitantly with anticonvulsants, can lower the seizure threshold. Increased oxcarbazepine dose may be required because of decreased exposure to monohydroxy derivative MHD [active metabolite]. There were 52 geriatric patients greater than 65 years of age in controlled clinical trials of oxcarbazepine and patients more than 65 years of age in other trials.
ST Step Therapy Drugs that have step therapy associated with each prescription.
Monitor patients for adverse reactions and breakthrough fungal infections if these drugs are coadministered. Although oxcarbazepine is a CYP3A4 inducer, autoinduction has not been observed because reduction is its primary metabolic route.
It works by decreasing nerve impulses that cause seizures. Do not start, stop, or change the dosage of any medicines without your doctor's approval.
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Skin and Subcutaneous Tissue Disorders: What should I know regarding pregnancy, nursing and administering Trileptal to children or the elderly? Store at room temperature away from light and moisture. The effects of severe hepatic impairment have not been evaluated. The prescribed amount of oral suspension should be withdrawn from the bottle using the oral dosing syringe supplied.
Moderate Caution is warranted when oxcarbazepine is administered with vinorelbine, as there is a potential for the metabolism of vinorelbine to be affected, decreasing drug efficacy. Therefore, MHD exposure in these children is expected to be about one-half that of adults when treated with a similar weight-adjusted dose. Concurrent use may decrease the plasma concentrations of bromocriptine resulting in loss of efficacy.
Folic acid deficiency, hypothyroidism Skin and appendages: Moderate Caution is recommended during concurrent use of tasimelteon and oxcarbazepine. In addition, concomitant use of clomipramine and oxcarbazepine may result in additive CNS depression. Patients taking these hormones for other indications may need to be monitored for reduced clinical effect while on oxcarbazepine, with dose adjustments made based on clinical efficacy.