Intravenous amiodarone atrial fibrillation

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The major metabolite of amiodarone is desethylamiodarone DEAwhich is known to have antiarrhythmic properties. The dosage of amiodarone should be kept at the lowest effective level. Community acquired acute kidney injury: One meta-analysis of 13 studies of patients with congestive heart failure or recent myocardial infarction showed a small reduction in total annual mortality, from No adverse reactions were encountered during the bolus injection but we recommend that continuous infusion be carried out through a central venous catheter to avoid phlebitis.

Chest radiograph; pulmonary function tests, including D lco. Increased cyclosporine plasma concentration. Therefore, physicians must use the lowest possible dosage of amiodarone and, if possible, discontinue treatment if adverse effects occur.


Optic neuropathy and optic neuritis, sometimes progressing to total blindness, have been described in a small number of patients treated with amiodarone. Intravenously administered amiodarone is effective for the emergency treatment of ventricular tachyarrhythmias. We request your email address only as a reference for the recipient.

Stop amiodarone; initiate corticosteroid therapy. History and physical examination directed at detecting anticipated adverse effects.

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Digoxin level, prothrombin time, and INR, when appropriate. A much less common presentation is adult respiratory distress syndrome. The ABC death risk score: Amiodarone has been associated with toxicity involving the lungs, thyroid gland, liver, eyes, skin, and nerves Table 2. Amiodarone and digoxin blood levels were determined. Get immediate access, anytime, anywhere.

To continue reading this article, you must log in with your personal, hospital, or group practice subscription. Gastrointestinal side effects of amiodarone include nausea, anorexia, and constipation.

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Intravenously administered amiodarone causes heart block or bradycardia in 4. Because phlebitis may occur, the drug should be given through a central venous line when possible.

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Therefore, all patients should be cautioned to use sunblock and, whenever possible, to cover exposed skin when they are outdoors. Minor effects Nausea, anorexia 30 2 History, physical examination Reduce dosage.

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Pulmonary function tests, including D lco. Amiodarone as compared with lidocaine for shock-resistant ventricular fibrillation [Published erratum appears in N Engl J Med ; Amiodarone is used in the treatment of atrial fibrillation, although the FDA has not approved this indication.

Amiodarone Trials Meta-Analysis Investigators. Treatments of amiodaroneinduced hyperthyroidism include the withdrawal of amiodarone if this can be done safelythe addition of antithyroid medications or prednisone, and surgical thyroidectomy.