Can azathioprine affect fertility
What is the most important information I should know about Imuran (azathioprine)?
Some people using azathioprine have developed a rare fast-growing type of lymphoma cancer. Nevertheless, these treatments remain powerful therapies that require skilful handling; therefore it should be borne in mind that the long-term consequences are still not fully understood. These statements have not been evaluated by the FDA. In contrast, the folic acid antagonist methotrexate has been documented to be teratogenic if administered during the first trimester.
Skip the missed dose if it is almost time for your next scheduled dose. Long-term effects of exposure to disease-modifying drugs in the offspring of mothers with multiple sclerosis: A sperm cryopreservation is recommended before instauration of the treatment in a male subject because of the mutagenic effect.
For some drugs that have fewer data but seem reassuring, the use may be continued during the pregnancy if needed anti-TNF alpha, mTOR inhibitors. Continue Shopping Check Out. The AMH concentrations of patients treated with azathioprine, mycophenolate or calcineurin inhibitors for lupus were not lower than in the control population [ 19 ].
Azathioprine is teratogenic in animals, as treated pregnant females and their foetuses have presented with chromosomal abnormalities on the circulating lymphocytes. Abatacept and anankira appear to be associated to a lesser extent with side effects than the anti-TNF alpha agents, infliximab in particular [ 3486 ]. There is no data on the effects of mycophenolate on male fertility.
What is Imuran (azathioprine)?
Sirolimus may reduce fertility in male renal transplant recipients. Most of the time, the intensity of immuno-suppression decreases with time, especially after the first year in allogeneic organ transplantation. We comply with the HONcode standard for trustworthy health information - verify here. You may not be able to continue taking other arthritis medications together with azathioprine. Therefore there are no recommendations to stop treatment if conception is desired [ 30 ].
It must be anticipated very far in advance, before the prescription of the immunosuppressants, in order to preserve fertility, and then before conception in order to adjust the immunosuppressive treatment. In other situations, if continuation of the therapy is required for good control of the treated disease, the lowest possible dose should be used during pregnancy.
Pregnancy, when an option, must be planned under conditions of strict monitoring, when the disease is not in an acute phase. The use of glucocorticoids has consequences on fertility [ 50 ].
Diagnosis might be clinical by examination of a newborn. Recording all the cases of anomalies recorded with a given treatment may help to understand the mechanisms and avoid further occurrence.
In humans, it is a confirmed teratogenic agent that promotes IUGR, malformation of the extremities and the head ocular involvement, facial dysmorphia, craniostenosis, hydro- or microcephaly. Induction immunosuppressive treatments The effects of induction treatments rabbit anti-human thymocyte immunoglobulins; interleukin-2 receptor antagonists such as daclizumab; belatacept on fertility and pregnancy have not been studied.