Colcrys interaction with grapefruit

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They are available 24 hours each day, 7 days per week, through email, online chat or by mobile. Conclusions In contrast to label warnings based on the literature, grapefruit juice did not affect the pharmacokinetics of colchicine.

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Seated blood pressure and pulse will be measured prior to dosing and at approximately 1, 2, and 3 hours following drug administration on Days 1 and 18 to coincide with peak plasma concentrations of colchicine. Epub Aug Colcrys colchicine US prescribing information.

Do not take extra medicine to make up the missed dose.

FDA Homepage

The Colcrys brand of colchicine is FDA-approved to treat or prevent gout in adults, and to treat a genetic condition called Familial Mediterranean Fever in adults and children who are at least 4 years old.

Follow all directions on your prescription label. Significant Potential for significant interaction monitoring by your doctor is likely required. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables. Try the new test version at https: Department of Health and Human Services.

Contrary to the expected effects of inhibiting the enzymes that metabolize colchicine, neither juice increased exposure to colchicine. To view content sources and attributions, please refer to our editorial policy. How the interaction occurs: Do not start, stop, or change the dosage of any medicine before checking with them first.

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Make sure your doctor knows if you have any kidney or liver problems, which may make the interaction worse. Subjects will consume the final administered dose of grapefruit juice 1 x ml in the evening on Day This information is generalized and not intended as specific medical advice. Grapefruit Juice mL of grapefruit juice ingested twice daily at 7: All study subjects will be monitored for adverse events throughout the study period.

Objective Two Phase I studies assessed the effects of multiple daily consumptions of Seville orange juice or grapefruit juice on the pharmacokinetic properties of colchicine in healthy volunteers.

West-Ward Pharmaceuticals Prasco Laboratories. Colchicine affects the way the body responds to uric acid crystals, which reduces swelling and pain.

Ages Eligible for Study: