Zovirax iv prescribing information
This medication is used in certain people to treat outbreaks of herpes simplex infection of the skin e. Do not double the dose to catch up.
Renal clearance of aciclovir is substantially greater than creatinine clearance, indicating that tubular secretion, in addition to glomerular filtration, contributes to the renal elimination of the drug. Consult your pharmacist or local waste disposal company.
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In a study of 20 male patients with normal sperm count, oral aciclovir administered at doses of up to 1g per day for up to six months has been shown to have no clinically significant effect on sperm count, motility or morphology. In clinical studies, the average kg adult received between 60 and mL of fluid per dose.
It is usually given every 8 hours. In adults, mean steady state peak plasma concentrations C ss max following a one-hour infusion of 2. It is recommended to measure plasma concentrations during concomitant therapy with aciclovir.
Understand Immunotherapy Painful Knees? The only major urinary metabolite detected is 9-carboxymethoxymethylguanine accounting for up to Previous Next Find Lowest Prices.
The solution in the vial is ready for further dilution prior to infusion. The Wellcome Foundation Ltd. Care is required if administering i. Brand and Other Names: Significant - Monitor Closely.
Immunocompromised patients with Varicella zoster infections or patients with herpes encephalitis should be given Zovirax I. In patients receiving intravenous Zovirax caution is required during concurrent administration with drugs which compete with aciclovir for elimination, because of the potential for increased plasma levels of one or both drugs or their metabolites.
The risk of renal impairment is increased by use with other nephrotoxic drugs.
Using plaque-reduction assays, the IC 50 against herpes simplex virus isolates ranges from 0. Slow intravenous infusion over 1 hour.
Controlled studies in pregnant women show no evidence of fetal risk. Sodium hydroxide For the full list of excipients, see section 6.
Intravenous doses should be given by infusion over one hour to avoid precipitation of aciclovir in the kidney; rapid or bolus injection should be avoided. Qualitative and quantitative composition 3. When diluted in accordance with the recommended schedules, Zovirax I.