Danazol lupus thrombocytopenia

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These include down-regulation of autoantibody production, neutralization of pathogenic autoantibodies by anti-idiotypic antibodies, inhibition of complement-mediated damage, modulation of cytokine production, induction of apoptosis in lymphocytes and monocytes, and modulation of both B- and T-lymphocyte function [ 69 ].

Scand J Haematol ; A number of novel therapeutic approaches to the management of cytopenias, including thrombopoeitin receptor agonists and anti-B-cell therapies, in particular, are showing great promise. Human parvovirus B19 infection during the inactive stage of systemic lupus erythematosus. Eltrombopag for thrombocytopenia in patients with cirrhosis associated with hepatitis C.

Given the important role for the spleen in the clearance of immune complexes, a risk of a flare in disease activity has been suggested following splenectomy in SLE [ 35 ], but this is not generally born out in practice. Of the remaining five patients, four had complete responses. Recurrent infections are the only known significant consequence of neutropenia.

Long-term safety has been addressed in an ongoing open-labelled single-arm study.

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Its use in SLE beyond glomerulonephritis is likely to increase, and it remains a promising therapy for the management of its haematological manifestations. Danazol for the treatment of refractory autoimmune thrombocytopenia in systemic lupus erythematosus.

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Fortunately, suppression of granulocytopoiesis rarely results in severe neutropenia. There are also reports of its use in the management of refractory haemolytic anaemia and thrombocytopenia complicating SLE [ 93—96 ].

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Register a new account? A phase II, randomized, double-blind, placebo-controlled, dose-ranging study of belimumab in patients with active systemic lupus erythematosus. Very low dose cyclosporin or vincristine can also be considered.


Patient eligibility criteria for second-line therapy have been proposed 43 table 3. There were no conclusions drawn on the nature of antigen recognition of neutrophils by the antibodies in this SLE serum. Complete remission in severe aplastic anemia after high-dose cyclophosphamide without bone marrow transplantation.

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Antilymphocyte antibodies have long been held responsible for the decline in lymphocyte numbers and in lymphocyte function. However, significant alterations were not seen in anti-dsDNA antibody levels. Mycophenolate mofetil as a treatment for autoimmune haemolytic anaemia in patients with systemic lupus erythematosus and antiphospholipid syndrome.

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Of these 59 patients, 57 received oral glucocorticoid as first and sole therapy; and of these, 50 were evaluated long term the remaining 9 received some other therapy in addition to glucocorticoid and were excluded from the evaluation. Mycophenolate mofetil or intravenous cyclophosphamide for lupus nephritis. Sequential sample of six patients with systemic lupus erythematosus with severe autoimmune thrombocytopenia refractory to high-dose glucocorticoids.

Some manifestations of lupus occur more frequently in association with low platelet count in these patients, for example, neuropsychiatric manifestation, haemolytic anaemia, the antiphospholipid syndrome and renal disease. Some authors, but not all, 40 have shown that lymphopenia correlates with disease activity.