Dosage of azithromycin for urethritis

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We found that a single 1-g dose of azithromycin is as effective as the standard seven-day doxycycline regimen in the treatment of C. Nineteen of the patients given azithromycin 15 female and 4 male and 15 of the patients given doxycycline 9 female and 6 male were asymptomatic and had no signs of infection at the base-line visit; therefore, the clinical responses of azithromycin-treated patients 83 female and 39 male and doxycycline-treated patients 78 female and 32 male could be evaluated at one or more follow-up visits.

Expedited partner treatment is a CDC-recommended strategy for situations in which the patient's sexual partners are otherwise likely to go untreated. CrossRef 37 David K.

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Compliance with the doxycycline regimen was documented at the first follow-up visit by counting the number of pills remaining and reviewing the patient's history. Am J Emerg Med. Persons who have persistent or recurrent urethritis can be retreated with the initial regimen if they did not comply with the treatment regimen or if they were reexposed to an untreated sex partner. N Engl J Med ; Apr 08, Author: To maximize compliance with recommended therapies, medications should be dispensed on-site in the clinic, and the first dose should be directly observed.

Patients with concomitant gonococcal infections were treated with a single mg dose of ceftriaxone given intramuscularly either at the initial visit or at the first follow-up visit.

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General advice Diagnose urethritis if there is urethral discharge present or if symptoms are in a high-risk patient. Evaluation of Treatment Only patients with positive C. Indicated for treatment of infections caused by susceptible strains of microorganisms, including Staphylococcus aureus. Antibiotic therapy with 2 g metronidazole or tinidazole is also recommended for sexual partners of individuals with documented Trichomonas, even if asymptomatic.

Non-gonococcal urethritis and cervicitis: Most had clinically evident urethritis or mucopurulent cervicitis, but some were asymptomatic sexual partners of patients with proved C.

C 161920 Based on expert guidelines Treatment of urethritis may reduce the transmission of human immunodeficiency virus. This drug has shown activity in vitro and in clinical infections against most isolates of Staphylococcus aureus, Streptococcus pneumoniae, S pyogenes, S agalactiae, Haemophilus influenzae, Haemophilus ducreyi, Moraxella catarrhalis, Neisseria gonorrhea, Chlamydophila pneumoniae, Chlamydia trachomatis, Mycoplasma pneumoniae, Mycoplasma hominis, Legionella pneumophila, and Mycobacterium avium complex.

Chlamydia can be found in anus, but usually asymptomatic and no FDA-approved test. CrossRef 3 Georgina F. Association of Mycoplasma genitalium with balanoposthitis in men with non-gonococcal urethritis. If clinically-based diagnostic tools eg, Gram-stain microscopy are not available, treat patients with drug regimens effective against gonorrhea and Chlamydiaas follows:. Postexposure prophylaxis of sexually transmitted diseases in survivors of sexual assault.

To confirm the diagnosis of C. Less than 1 month: At the last follow-up visit, 97 percent of the male patients and 98 percent of the female patients had responded clinically to azithromycin, as compared with 91 percent of the male patients and 95 percent of the female patients treated with doxycycline difference in rates of clinical improvement for male patients, 6 percent; 95 percent confidence interval, 0 to 17 percent; difference in clinical rates of improvement for female patients, 3 percent; 95 percent confidence interval, 0 to 9 percent.

Seventeen percent of the patients who received azithromycin and 20 percent of those treated with doxycycline had mild-to-moderate drug-related side effects, mainly gastrointestinal symptoms. Salvador Alvarez-Elcoro, Mark J.

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Finally, false negative culture results are expected in 10 to 15 percent of patients with chlamydial infections even under ideal conditions.