Levosulpiride vs domperidone

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No side-effects requiring intervention were recorded and laboratory tests, electrocardiogram and arterial pressure were not modified Levosulpiride possesses paradoxical clinical effects in that its therapeutic activity is dependent on the dose that is administered.

How to cite this article: Its efficacy may be related to its action on the gastric motor function by improving the delayed gastric emptying.

The mean duration of gastrointestinal symptoms prior to entry in the study was 4. A study comparing cisapride and metoclopramide showed no differences in the improvement of symptoms or in gastric emptying delay. The clinical use of Levosulpiride.

Force velocity characteristics of esophageal muscle effect of acetylcholine and norepinephrine. What are the respective advantages of the different prokinetic agents at the disposal of the gastroenterologist? Levosulpiride ; Functional dyspepsia ; Gastric emptying.

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Levosulpiride, a dopaminergic antagonist was compared in a double-blind randomized study with domperidone for treatment of functional dyspepsia in 50 patients divided into two groups of 25 subjects each. It causes the release of acetylcholine from enteric neurons, an effect that is antagonized by both tetrodotoxin and corticholinergics. Gastric emptying time was measured by means of 13 C-octanoic acid breath test as previously described.

Nagler J, Miskovitz P. This cut off value was established on the basis of our laboratory normal range, which is Gastric emptying times before and after 3 weeks of treatment with placebo or levosulpiride.


The 13 C-octanoic acid breath test procedure was satisfactory. Finally, among the available prokinetics drugs, the benefit from treatment with cisapride is well documented. Although metoclopramide provides symptomatic relief from acid reflux its effectiveness in healing esophagitis lesion is less convincing [ 7 ]. Cure of Helicobacter pylori infection does not improve symptoms in non-ulcer dyspepsia patients-a double-blind placebo-controlled study.

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Side effects from bethanechol have to be taken into account in the treatment of esophageal disease, mainly gastroesophageal reflux GER. Both drugs had a positive influence on dyspeptic symptoms and on gastric and gallbladder emptying, but the latter parameters were improved significantly more effectively by levosulpiride.

A double-blind placebo-controlled evaluation of cisapride. Symptoms and anxiety associated with these disorders frequently are inconvenient and put off individuals affected from leading full and industrious lives [ 1 ]. Biochemical investigation like complete hemogram, serum creatinine, blood glucose and liver function tests etc.

Levosulpiride is a prokinetic agent which amplifies the lower esophageal sphincter pressure more speedily and efficiently than other therapeutic agents [ 11 ].

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