Sporanox precautions posologie
Plasma concentration-versus-time profiles showed wide intersubject variation in all three groups. Hepatic Impairment Itraconazole is predominantly metabolized in the liver.
Effect of protein binding: Alitretinoin oral Cabergoline Cannabinoids Cinacalcet Ivacaftor. The most common side effects include: Itraconazole clearance decreases at higher doses due to saturable hepatic metabolism.
Do not flush medications down the toilet or pour them into a drain unless instructed to do so.
SPORANOX capsules are also contra-indicated in patients with a known hypersensitivity to itraconazole or its excipients, other azole antifungal agents or any of the excipients. Commonly susceptible species Aspergillus spp. Treat systemic infections for at least 3 months.
At least 12 months and until CSF abnormalities resolve and histoplasmal antigen is undetectable Secondary prophylaxis suppressive therapy: Antimigraine Drugs Ergot alkaloids e.
Oropharyngeal candidiasis in patients 5 years or older: Absorption of itraconazole capsules is reduced in subjects with reduced gastric acidity, such as subjects taking medications known as gastric acid secretion suppressors e.
Caution should be exercised when this drug is administered in this patient population see section 5. Neither Everyday Health nor its licensors endorse drugs, diagnose patients or recommend therapy. In addition, itraconazole can inhibit the metabolism of calcium channel blockers.
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Table 1 lists examples of drugs that may have their concentrations affected by itraconazole, but is not a comprehensive list. Store at 15C to 25C 59F to 77F ; protect from light and moisture. The CLSI breakpoints are: No special requirements for disposal. See also Table 2. Patients should be instructed to promptly report to their physician signs and symptoms suggestive of hepatitis such as anorexia, nausea, vomiting, fatigue, abdominal pain or dark urine.
Transient or permanent hearing loss Cardiac Disorders: Drugs affecting the metabolism of itraconazole: These risk factors include cardiac disease, such as ischemic and valvular disease; significant pulmonary disease, such as chronic obstructive pulmonary disease; and renal failure and other edematous disorders.
May give loading dose of mg 3 times daily for 1 st 3 days.