Blood level of phenytoin
Phenytoin is a powerful, effective medication for treating and preventing seizures but it may cause serious side effects and, infrequently, liver damage. Concomitant use of valproic acid alters free phenytoin levels by competitively binding to serum albumin.
A phenytoin test may be recommended if a patient does not seem to be responding to the medication. Free phenytoin levels should be measured to provide the most accurate assessmet of phenytoin acivity early in therapy.
Because this disorder is variable in its expression, other organ systems not noted here may be involved. About Us Disclaimer Contact Us. Only Dilantin extended phenytoin sodium capsules, USP are recommended for once-a-day dosing. Advise patients taking Dilantin not to drive, operate complex machinery, or engage in other hazardous activities until they have become accustomed to any such effects associated with Dilantin.
Check for evidence of dysrhythmia, severe clinical presentation, or multiple medication ingestion. No special preparation is needed prior to the test. However, patients should be cautioned not to miss a dose, inadvertently. What are some useful resources for additional information? Measure ethanol level for multiple ingestions or altered mental status.
The significance of Phenytoin Blood Test is explained: Obtain a complete blood count CBC to rule out anemia, eosinophilia, atypical lymphocytosis, and pancytopenia. A small percentage of individuals who have been treated with phenytoin have been shown to metabolize the drug slowly.
Are allergic to phenytoin or any of the ingredients in Dilantin. In the intentional overdose setting, immediately perform a dextrose fingerstick test in any patient with altered mental status.
The most common side effects of Dilantin include: These are not all of the possible side effects of Dilantin. If the levels are too low, the drug may not successfully ward-off a seizure attack A Phenytoin Blood Test is a test that assesses the levels of phenytoin in blood.
Differences in formulation between brand names and generic equivalents can result in altered bioavailability, causing toxicity or the development of subtherapeutic levels. Irreversible cerebellar dysfunction and atrophy have been reported. In addition to monitoring renal function, hepatic function, and albumin levels, physicians should be aware of antifolate and anti—vitamin K properties of phenytoin in pregnant women.
Have or have had depression, mood problems, or suicidal thoughts or behavior Have had an allergic reaction to a medicine similar to Dilantin called carboxamides, barbiturates, succinimides, and oxazolidinediones Have or had liver or kidney problems Have or had an enzyme problem called porphyria Have or had high blood sugar hyperglycemia Drink alcohol Are pregnant or plan to become pregnant.
Many more drugs interact with phenytoin, so tell your health practitioner about any prescription or over-the-counter drugs, supplements, or herbal products you take. However, by downloading it you agree to not change, edit, alter the image or file and agree that the EBM Consult logo is displayed and appropriate acknowledgement of the image or file has come from EBM Consult. Print this section Print the entire contents of.