Aprilia 5 lidocaine prilocaine
Other reported clinical experience has not identified differences in responses between the elderly and younger patients, but greater sensitivity of some older individuals cannot be ruled out.
No overall differences in safety or efficacy were observed between these patients and younger patients. Patients allergic to paraaminobenzoic acid derivatives procaine, tetracaine, benzocaine, etc. A secondary protective covering to prevent inadvertent disruption of the application site may be useful.
A protective covering of the Cream is not necessary for absorption but may be helpful to keep the cream in place.
Reproduction studies have been performed in rats receiving subcutaneous administration of an aqueous mixture containing lidocaine HCl and prilocaine HCl at 1: EMLA lidocaine and prilocaine Cream was studied in full term neonates gestational age: Prilocaine is metabolized in both the liver and kidneys by amidases to various metabolites including ortho -toluidine and N-n-propylalanine. Studies in laboratory animals guinea pigs have shown that EMLA lidocaine and prilocaine Cream has an ototoxic effect when instilled into the middle ear.
Most patients recovered spontaneously after removal of the cream. Systemic Dose Related Reactions: EMLA Cream is a eutectic mixture of lidocaine 2. Twenty-nine patients received 10 g of EMLA lidocaine and prilocaine Cream applied for 10 to 60 minutes in the vaginal fornices.
Plasma levels of lidocaine and prilocaine in geriatric and non-geriatric patients following application of a thick layer of EMLA lidocaine and prilocaine Cream are very low and well below potentially toxic levels.
After a 5 to 10 minute application of EMLA lidocaine and prilocaine Cream to female genital mucosa, the average duration of effective analgesia to an argon laser stimulus which produced a sharp, pricking pain was 15 to 20 minutes individual variations in the range of 5 to 45 minutes.
Local anesthetic infiltration should be performed immediately after removal of EMLA lidocaine and prilocaine Cream.
EMLA lidocaine and prilocaine Cream is not recommended in any clinical situation when penetration or migration beyond the tympanic membrane into the middle ear is possible because of the ototoxic effects observed in animal studies see WARNINGS.
Also the loss of protective reflexes can permit corneal irritation and potential abrasion.
These results illustrate the importance of emotional and psychological support of younger children undergoing medical or surgical procedures. The systemic blood levels depend on the amount absorbed and patient size weight and the rate of systemic drug elimination. Long duration of application, large treatment area, small patients, or impaired elimination may result in high blood levels.
Ortho -toluidine, a metabolite of prilocaine, at a concentration of 0.
EMLA lidocaine and prilocaine Cream 5 to 10 g applied between 1 and 75 minutes before surgerywith a median time of 15 minutes, provided effective local anesthesia for minor superficial surgical procedures. These cases involved the use of large doses, larger than recommended areas of application, or infants under the age of 3 months who did not have fully mature enzyme systems.
Excitatory CNS reactions may be brief or not occur at all, in which case the first manifestation may be drowsiness merging into unconsciousness.